Luis De Jesus Los Angeles is dedicated to showcasing a diverse roster of artists whose work engages with regional and global dialogues while exploring a wide range of social, cultural, and aesthetic ideas. The gallery's program has garnered recognition, with artists receiving prestigious awards, participating in international biennials, and having their work acquired by major museums and institutions.

Luis De Jesus and Jay Wingate opened their first gallery, Luis De Jesus Seminal Projects, in San Diego in 2007.  In 2010, they rebranded as Luis De Jesus Los Angeles and opened in Santa Monica's Bergamot Station. In 2011, the gallery relocated to the Culver City Arts District where it operated for ten years. In the spring of 2021, the gallery opened its current home — an expansive space in a classic bow & truss building on the edge of the Los Angeles Arts District.